Great debate everyone, very rare for the internet.
Okay, here's something that I believe is worth thinking about.
One For All is supposed to be a power that is used to transfer energy. Furthermore, this power has been cultivated, or "trained" if you'll allow me to use the word, to be used in different ways.
Gran Torino has said that "All Might" had a body that was perfectly suited for this ability. Even so, perhaps All Might trained the ability in a way that is too dangerous for a brand new user to adopt. Especially someone who has focused on building intellect and knowledge instead of athleticism.
I wonder if Izuku is going to be the one to train One For All in a way that makes subsequent users able to heal immediately from the use of the ability. Deku's smart, and he realizes that damaging his own body with an ability that channels the strength of all the previous users is a bad side effect. Maybe Deku will be the one to "perfect" the quirk to the point that anyone else who inherits it will be able to use it without hurting themselves - maybe he'll use the energy to enhance his own endurance and healing to compensate for the excessive force that he generates.
Leave it to a smart kid to minimax the problem.
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Or... or... what if. What if Deku gives a hair to each classmate to eat. And then, together, the classmates train OFA, and then give hairs back to Deku.
What if?!?!?!
Interesting.
All Might does that Hulk transformation thing. Maybe that's a talent he trained himself to do. If that's the case then Deku using OFA in a unique way, like a limited healing factor, is possible too.