that would be a fun chapter, deposing Tsunade just because of "Hey Tunsa it's (insert new Kage name), so come on … step down now! or we will be FORCED to remove you!" (because as much as I can remember about Hokage, it was an appointment for life; no one willingly stepped down unless they were about to die ... and thanks to her slug, Tsunade is no longer in that situation)
The 3rd stepped down and I mean - considering he retook the position - it didn't seem he was so close to die when he retired.