Personally I believe Rei did what she could considering her circumstances, part of the reason Shoto started to heal was the "You are not a prisoner of your blood" memory. Regarding Touya, she tried and it doesn´t matter what she told him, since only Endeavor´s words would have made a difference. She even told Endy what the kid wanted and that he was simply running away, she couldn´t have been more clear.
Now regarding Fuyumi and Natsuo, I don´t think she neglected them by choice, but it was the result of having to protect Shoto from Endeavor. They clearly understand that and don´t hold it against her, hell, even Shoto knows that the burning incident was a moment of weakness caused by Enji´s abuse.
@King:
They clarified this on Twitter. Rei was not supposed to mean "Once Touya was gone".
Oh, I just saw this, that´s good to know, thanks.
@Nectar:
What?! I look forward to those especially when I'm confused about something in a chapter. It's one of the few reasons I go on Twitter. People had access to the best source of chapter by chapter information and ruined it.
Caleb really made an incredible effort each week, they really didn´t deserve him. I hope he knows a lot of the fandom really appreciates him and his work.