After this most recent chapter, I feel that this arc is starting to set precedence for how the New World stuff will work.
First of all, take away a number of the established beliefs set in the Grandline. Especially by the end of the Grandline part with the war, we had established hierarchy of stuff. Admirals and Yonko were almost untouchable, especially by the straw hats and supernovas. The shikibukai were strong, but nowhere close to the level of Admiral/Yonko. Logias were some of the most troublesome users to fight. And so on and so forth. With Luffy ready to not run away from an Admiral, it's time to establish how far away he is now. While he isn't ready to beat one (going by where we are in the story), we need to establish how far he has to go. This will give us a baseline, but at this point we can't definitely say anything about how any confrontation will go based on titles at this time.
Second is with Yonkos being the focus, and with this last arc, there is going to be a change in how arcs are done. Before, the antagonists were trying to reach a goal, whether it be taking over a kingdom or getting blue prints. At this time, the powers have been established and are waiting for the right time for their plans. That means the arcs going forward for now are going to be with the antagonists being on the defensive, and trying to retain their position, just like Doflamingo was trying to keep his kingdom and business.
Last but the biggest is going to be how things will change at any time. Dressrosa definitely set a precedent for this, as things were constantly changing. Law had a plan, Doflamingo countered it. Some characters out of his control change the situation, allowing things to go against him. Usopp has a bunch of new allies, but many suddenly turn on him. The biggest instance is the KHA alliance, where they want to go after Shanks, then Kaido just appears out of no where. We could go further back and show when the Supernovas entered the New World, where all the random stuff just happened. Basically, things are going to keep changing, and predicting the flow of stuff is going to be much harder in certain aspects.