Well I rather see ES21 end on a cool note with Ojou winning and everyone getting ready for the next year. I mean if they beat Ojou, then they'll face the wild gunmans in a practical repeat of the last game.
Or the Gunmans can lose to the dino-team in which case that would totally suck since it doesn't make much sense for a team like the gunmans to lose to anyone other than the Devilbats, White Knights or Shinryuji.
Either way I see Eyeshield is going to be really hard to end properly since the creator made some teams invincible and the fact that he already showed the Devilbats playing against every strong team out there. Except for the dino-one, but like I said the wild gunmans losing wouldn't make much sense and it would piss everyone off since they were created to be practically invincible.
I don't mean to be negative but come on what I'm saying is correct. The creator dug himself into a pretty big hole where he's either forced to end the series, rehash a previous matchup that took like 15 chapters, or make a invincible team lay down to create a new matchup that wouldn't make much sense considering that the devilbats just trampled over the 2 strongest teams ever (Nagas and White Knights).