Not gonna plug my own pod (because… the link's... I plug it in my sig. I've already done it. I'VE ALREADY DONE IT), but here's a few things I enjoy a whole bunch at present:
http://psycomedia.wordpress.com/ - Psycomedia is a psychology and comedy pod wherein two handsome english gentlemen take a look at some odd case studies and the like and make you laugh while they do it. Highly recommended for anyone with a brain (full disclosure, Tim Swann on the pod is a former and possibly future collaborator of mine on an old pod series Tim & Max Solve All The Problems With Popular Culture, so I'm a little biased)
http://unansweredpodcast.wordpress.com/ - Unanswered is a pretty new pod where two blokes talk about something aimlessly for a while, making gags and heartfelt observations, before putting the subject back where it came from, undealt with and unanswered. It's charming, trust me.
http://www.savagecritic.com/ - One with a bit of a manga touch here, Wait What is a podcast over at the Savage Critics, where Jeff and Graeme talk about comics and comics media at some length, including the occasional dip into Viz Media's Shonen Jump Alpha and other digital output. It's got lengthy episodes, but they talk about stuff in depth and really get to the bones of each comic/news piece/et ceteraThat'll do for now. Check 'em out, why don't you?
I bet my podcast is like a million bajillion times better so hmmf
Also have a listen over at Read It and Weep ( read-weep.com ), excellent podcast of improv comedians tackling user-submitted bad books, movies and TV.
Another great podcast for those who enjoy critical thinking, http://skeptoid.com is a 10-minute or so show dissecting paranormal and pseudoscientific claims