New main character is Nero (aka Nelo Angelo) and Dante is the villan. Don't worry Dante fans, he will still be playable. The story is based inbetween 1 and 2.
http://www.gamesarefun.com/news.php?newsid=6813
http://www.gameinformer.com/images/media/%7B3848B2AC-3B68-4596-A2A5-6056035715B0%7D/gi-3-dmc4.jpg
http://www.gameinformer.com/images/media/%7B3848B2AC-3B68-4596-A2A5-6056035715B0%7D/gi-1-dmc4.jpg
http://www.gameinformer.com/images/media/%7B3848B2AC-3B68-4596-A2A5-6056035715B0%7D/gi-2-dmc4.jpg