@Franky:
OP is my life. sounds stupid, i know, but that's how i feel. One Piece has effected my life so freaking much, it's unbelievable. OP Made me decide what i want to do in life. this is probably a cleashay, but OP made me belive in myself, and that i can achieve my desires and make my dreams come true if i want too. and my dreams are related to OP, Actually. i don't know if it's ok for me to tell you this 'cause probably some of you won't like the idea, but..oh well, what the heck.
Hey, there's definitely nothing wrong with anything positively affecting one's life. I remember a long time ago, I wanted to do something similar, except it was with Digimon, I wanted to work on the anime for it. I want to be a musician now, but regardless of everyone's dreams, whether for vocations, wanting to level up, or anything in life… Go for it. =D Even if the odds are against you, such as making a One Piece movie series people may or may not be against... Keep with it!
@HinaThePrince:
It always makes me happy when I think about it [unless I think about the angsty parts, which make me despressed] - it's like the shining light of this filthy world, or something. It makes me believe that someday my dream can come true, too.
But it also makes me kind of jealous - it's stupid, I know, but I wish I had nakama like that. I don't think anything like that exists in real life.
Me too. I think as life goes on, I'll make more, though. Maybe we can all be inspired/impacted nakama (as corny as that sounds, and as newbieish as I am..) together!
@EvilGamerX:
Wow, it is really nice to hear some of the stories I have read. To hear that it helped some of you with depression is something to admire. (Wish it did the same for me, but I'm too fucked up for that =P)
As for how One Piece impacted my life… Well, I was never as huge into manga as I am now.
For a more serious note, it acts as an escape alternative for me than alcohol. When I'm at my worst, I'll read some One Piece to help cheer me up. Sometimes I'll pathetically associate myself with a character and admire the character for how they act and gives me some belief that I can be like that. Be it storng (not in a strength context), carefree, or anything... it eases the soul a bit.
One Piece is my anti-drug. I don't mean to sound corny or make fun, but to be serious.
I used to think I was really pathetic that something fictional can help me a little. After reading all this, I know I was wrong.
Meh, this all probably sounded stupid.
That's definitely not stupid! That goes to anyone else who has thought they were pathetic for having their life positively changed in any way, whether small or drastically, through OP, or any other anime or art form or anything else! I was looking for a "inspired by OP" topic, which got me to this topic, and I thought if there wasn't one made yet and if I were to make it, how silly that kind of topic would've sounded… but now I see, how many people are affected, just like me! It's not pathetic at all...
Also, I too admire characters and relate to them. I think that's a universal thing. 
After reading all the replies in this topic... it's just great to hear how many people have been impacted from OP, in awesome ways... Curing depression, life values... different things. It just makes me... feel warm and fuzzy inside, I guess. That sounded corny, but oh well.
As for me... OP has taught me different things. Not to be scared of anything... To go for your goals and dreams even with impossible odds and obstacles against you! Of course I was already on my way with going towards those, but it just gave me more fuel (kinda like Franky with cola) to go after them EVEN MORE. It also makes me want to have nakama where I feel like I'm loved around just as much as each straw hat does in Luffy's crew. It makes me want to have the most adventurous, most fun life EVER.
And the story itself... I've never shed actual tears from OP, but the stories do affect me. I love the interaction between the characters, the sad drama,
the strength not only in attacks but in heart, watching everyone jump over their obstacles and get even more closer to their DREAMS! All of it. Even though I may not cry, I feel like I'm still very 'into' this series - I'm still affected somehow, as I always wish the best in my mind for everyone involved, to come out okay!
Wow, this kinda made me all emotional… Art can do that to you.