Synopsis from GI:
_Spider-Man is dead. After years of battling super villians and saving New York from bi-weekly disaster, the wall crawler meets a gruesome end. The superhero's death sends New York into a downward spiral. Crime reaches new heights as poverty and homelessness spread like viruses, By the year 2099, New York citizens live in fear of a near-totalitarian regime.
Above it all sits Alchemax, a mega corporation that has it's talons in everything from the commercial sciences and politics to organized crime. However this is not how history was supposed to transpire. The Universe is off balance, and only one person is aware of the time paradox. That man is Miguel O' Hara, brilliant geneticist who moonlights as the Spider-Man of the future. In order to save his own time, this Spider-Man will need to completely rewrite history._