I'm sure someone already brought this up somewhere but I'd enjoy the following.
A. Seems the Rolling Pirates are eager to even up with the Strawhats and that is probably going to end up being to the ends of self-sacrifice against Kuma giving them time to make a hasty departure.
B. This would be remarkably ambitious if he decided to go ahead with it, but I'd like to see one or two crew members get vanish-a-lised by Kuma and have them spend some time away from the crew. This would be interesting (IMHO of course) for a number of story reasons that Oda could add his signature twists to, but, I think it would also make for a nice break considering the crew is getting fairly well rounded out at this point and we could use something like that to throw a monkey-wrench in their ever-increasing capabilities.
"But they just lost Usopp and Robin."
No, Usopp committed mutiny and although yes, we were unsure of Robin's whereabouts for about 3 months, that all resolved itself fairly quickly with respect to motivations and knowing where characters actually stood. After they left we had a fairly good idea of where they were and what their intentions were. It'd be great to see someone just dumped somewhere and bit by bit follow them back while dealing with a big arc. I'm not interested in seeing the crew fight back to get their crew mate back, just kind of separate them suddenly and see how they come back together. Hell, the timing's right, mini-arc for a crew member. ^O^
I will admit, in my perfect dream world that will never happen, they would be sent to Impel Down which would require a massive jailbreak. Oh how I'd love to see an intricate 9-member jail break. Oh well, one of these days. Now that we have an idea of OP's length or at least the scale Oda is willing to take it to, I have no doubt we'll be spending plenty of time there before long.
Personally, even though it WILL NOT HAPPEN, I'd like to see Chopper get sent off and then finally get his '5th' chapter upon a heroic return.