Zou will not be destroyed.
I don't think Jack will succeed in killing Zoshina and destroying the mink's homeland.
In all of the OP storyline, time and time again some island/kingdom/home is threatened=
- by villians ruling the land = Arlong-Conomi Islands, Enel-Skypeia, Doffy-Dressrosa
- by villians trying to take over = Crocodile-Alabasta, Hody Jones-FI
- some random acts by invaders= Buggy -Orange Town .(This doesn't fit the above since Buggy wasn't trying to rule over the townsfolk, he was just raiding it) Don Krieg-Baratie (doesn't fit above as he wanted to steal it to use as a disguised pirate ship, not rule over the cooks)
While these locations received some damage and some areas may have been destroyed, the full region of the island/kingdom/town/home wasn't destroyed. Even in Skypeia, while Angel island and Shandian's village was destroyed, rest of Skypeia, including Upper Yard wasn't and the people were able to stay in the region.
Only twice were locations destroyed in OP that we've seen = Ohara and Enies Lobby. Both were separate circumstances than the above locations as they were destroyed not by a villain(as far as civilians & Marines see it. Many readers disagree) or rebel forces. They were destroyed by the Marines using the Buster Call , idealistically(on the Marine's side of viewing it) it was to deal with criminal issues
Ohara was destroyed due to the threat of the Historians investigating events of the Void Century and reading the Ponyglyphs. Both acts are illegal.
Enies Lobby was destroyed in attempt to deal with the SHs. Sure Spandam accidentally hit it. But the Marines did view the SHs as criminals (well they were, as both pirates and invading EL) so the view fits.
Also EL wasn't home to any friends of the SHs. While Ohara was, Robin's home was destroyed in the past and we saw it only in a flashback.
Zou doesn't fit pattern of locations destroyed by the Buster call but does fit as a location that had random act of violence by invaders.
Some may think my reasoning is flawed, others won't like it because it counters their view of the island being destroyed.
Don't really care (unless someone gives good (read intelligent and can back it up) counters to flaws) its my opinion of why I think Jack will ultimately fail in killing Zoshina and destroy Zou.